The effects of O-(beta-hydroxy-ethyl)-rutosides (HR) on acute lymphoedema in rats' thighs, with and without macrophages.
Identifieur interne : 00D969 ( Main/Exploration ); précédent : 00D968; suivant : 00D970The effects of O-(beta-hydroxy-ethyl)-rutosides (HR) on acute lymphoedema in rats' thighs, with and without macrophages.
Auteurs : J R Casley-Smith [Australie] ; J R Casley-SmithSource :
- Microcirculation, endothelium, and lymphatics [ 0740-9451 ] ; 1990.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Protéines.
- anatomopathologie : Lymphoedème.
- métabolisme : Lymphoedème.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : O-(bêta-Hydroxyéthyl)rutosides.
- Animaux, Lignées consanguines de rats, Macrophages, Membre pelvien, Mâle, Rats.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Proteins.
- chemical , therapeutic use : Hydroxyethylrutoside.
- drug effects : Macrophages.
- drug therapy : Lymphedema.
- metabolism : Lymphedema.
- pathology : Lymphedema.
- Animals, Hindlimb, Male, Rats, Rats, Inbred Strains.
Abstract
The effect of O-(beta-hydroxy-ethyl)-rutosides (HR), injected subcutaneously, was investigated on experimental acute lymphoedema in rat thighs. The oedema was reduced from a 30% increase over the normal weight, to one of 13%. When the macrophages were destroyed by the intraperitoneal injection of silica (for eight days before the initiation of lymphoedema) the oedema of the thigh increased to 41% - thus showing the importance of these cells in limiting high-protein oedemas. When HR was given to animals treated with silica the oedema was no longer reduced (42%). Thus HR reduces a high-protein oedema substantially via the macrophages.
PubMed: 2099387
Affiliations:
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Le document en format XML
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O-(beta-hydroxy-ethyl)-rutosides (HR) on acute lymphoedema in rats' thighs, with and without macrophages.</title><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name><affiliation wicri:level="1"><nlm:affiliation>Henry Thomas Laboratory (Microcirculation Research), Univ. of Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Henry Thomas Laboratory (Microcirculation Research), Univ. of Adelaide</wicri:regionArea><wicri:noRegion>Univ. of Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></author></analytic><series><title level="j">Microcirculation, endothelium, and lymphatics</title><idno type="ISSN">0740-9451</idno><imprint><date when="1990" 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xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxyethylrutoside</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>O-(bêta-Hydroxyéthyl)rutosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hindlimb</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lignées consanguines de rats</term><term>Macrophages</term><term>Membre pelvien</term><term>Mâle</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of O-(beta-hydroxy-ethyl)-rutosides (HR), injected subcutaneously, was investigated on experimental acute lymphoedema in rat thighs. The oedema was reduced from a 30% increase over the normal weight, to one of 13%. When the macrophages were destroyed by the intraperitoneal injection of silica (for eight days before the initiation of lymphoedema) the oedema of the thigh increased to 41% - thus showing the importance of these cells in limiting high-protein oedemas. When HR was given to animals treated with silica the oedema was no longer reduced (42%). Thus HR reduces a high-protein oedema substantially via the macrophages.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><noCountry><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></noCountry><country name="Australie"><noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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